A comparison of Membrane Pumps and passive transporters

NKAtpase

PMCA/SERCAtpase

HKAtpase

SGLT  similar to Na/AA Trans

NA K 2Cl Cotransport

3Na-Ca(NCX)Counter transport

Na-H(NHX

3Na/2K

1H/1Ca and 2H/2Ca

2H/2K

1Na/1Glucose

1Na, 1K, 2Cl

 Na moves downhill

Na downhill

1ATP

1ATP and 1ATP

1ATP

1ATP indirect (NKA)

1ATP indirect (NKA)

1ATP indirect (NKA)

Keep Intercellular [Na] low

Keep intercellular[K] high

PM and SR&ER

Keep cytoplasm [Ca] low

Parietal

Makes HCl

Related to dev. Stages from blood to cell. Cl to lumen

NCX keeps low intracellular Ca

pH reg. H secretion, Na absorption and cell V

Plasma membrane of All cells

PM and SR&ER

Parietal

Cardiac glycosides

High Na intake

PPI

High Glucose saturates SGLT (DM)